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Live Intranasal Influenza Vaccine Information Statement | CDC
Many countries recommend use of live attenuated influenza vaccines (LAIV) for children aged 2 years or older. The trivalent LAIV (LAIV-3) was licensed in the USA in 2003, and approved for use in the EU in 2011. The current quadrivalent formulation of LAIV (LAIV-4) obtained licensing during 2012-13, subsequently replacing LAIV-3.
Intranasal powder live attenuated influenza vaccine is ... - Nature
Recently, two randomized controlled trials (RCTs) assessing Russian-backbone trivalent LAIV in children reported contradictory results; vaccine efficacy varied between Bangladesh (41 %) and Senegal (0.0 %) against all influenza viral strains. Prior to 2013, Ann Arbor-based LAIV demonstrated superior efficacy as compared to IIV.
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Types of seasonal influenza vaccine - World Health Organization (WHO)
Abstract. The USA has a long-standing paediatric influenza vaccination programme, including use of live attenuated influenza vaccine (LAIV). Following US evidence of apparent lack of vaccine effectiveness (VE) of LAIV in 2015/2016, particularly against A (H1N1)pdm09, the USA suspended the use of LAIV in the 2016/2017 season.